542 Synergic complex of two plant flavonoids as a novel tyrosinase inhibitor

Tyrosinase is a key enzyme in melanin formation. Its inhibition crucial step for hyperpigmentation reduction. The aim of this study was to evaluate the efficacy two plant flavonoids: ellagic acid and glabradin, on tyrosinase as well their whitenning properties vivo. For reason IC50 acid, glabradin mixture reaction estimated. Kojic served reference sample. In addition vivo an emulsion with 14 patients performed. It occured that not typical inhibitor, however containing displayed greater than alone. Moreover complex showed much higher inhibitory activity kojic acid. Mexameter measurnments reduction by 15% after 4 weeks usage. Also estimated evened skin tone reducing visibility 24% (in 5-point analogue scale). Both tested compounds are known from whitening properties. Although but rather alternative substrate according literature. Nevertheless it’s boosting glabradin. conclusion, first time synergy demonstrated. both flavonoids exhibited efficient